SAB4200707

Anti-Desmin antibody, Mouse monoclonal

clone DE-U-10, purified from hybridoma cell culture

• 동의어(들): Anti-DES
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 항체 형태: purified from hybridoma cell culture
• 항체 생산 유형: primary antibodies
• 클론: DE-U-10, monoclonal
• 형태: buffered aqueous solution
• 분자량: antigen ~55 kDa
• 종 반응성: rat, rabbit, hamster, porcine, goat, bovine, chicken, toad, sheep, mouse, human
• 향상된 검증: independent; Learn more about Antibody Enhanced Validation
• 농도: ~1.0 mg/mL
• 기술: immunoblotting: 0.5-1 μg/mL using whole extract of mouse myoblast C2C12 cells; immunofluorescence: 2-5 μg/mL using mouse myoblast C2C12 cells; immunohistochemistry: 2.5-5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded Human Appendix; microarray: suitable
• 동형: IgG1
• UniProt 수납 번호: P02540
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... DES(1674) ; mouse ... Des(13346) ; rat ... Des(64362)

설명

일반 설명

Anti-Desmin antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma DE-U-10 produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/C mouse. Desmin, a major intermediate filament protein in skeletal, cardiac and smooth muscle cells. It is predominantly localised to filamentous extrasarcomeric cytoskeleton, which links neighbouring myofibrils and connects the myofibrillar apparatus with the subsarcolemmal cytoskeleton, myonuclei and mitochondria.

면역원

Desmin purified from pig stomach

애플리케이션

Anti-Desmin antibody, Mouse monoclonal has been used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry
• microarray

생화학적/생리학적 작용

Mutations is the desmin gene (known as desminopathy or DRM) are associated with several human diseases such as atrophy and facial muscle weakness, cardiomyopathy, cardiac arrhythmias and restrictive heart failure and are characterized by intracellular desmin aggregates. Anti-Desmin antibodies can be implemented for cancer research and diagnostics since elevated levels of desmin characterize several types of muscle tissue tumors, such as leiomyomas and rhabdomyosarcomas. The antibody may also be used for meat research measurements.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable