추천 제품
항체 형태
culture supernatant
Quality Level
항체 생산 유형
primary antibodies
클론
TM4SF-11, monoclonal
양식
buffered aqueous solution
분자량
antigen ~27 kDa
종 반응성
rat, human, canine, monkey, mouse, bovine
기술
immunoblotting: 1:4,000-1:8,000 using whole extract of HCT-116 cells
동형
IgM
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TM4SF4(7104)
mouse ... Tm4sf4(229302)
rat ... Tm4sf4(116467)
일반 설명
Anti-TM4SF4 antibody, Mouse monoclonal (mouse IgM isotype) is derived from the TM4SF-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with synthetic peptide from the internal region of human TM4SF4, conjugated to KLH. TM4SF4 (Transmembrane 4 L6 Family member 4) also known as ILTMP (intestine and liver tetraspan membrane protein) is a member of the transmembrane 4 superfamily (or tetraspanin family). It is a cell surface glycoprotein containing four transmembrane domains.
면역원
synthetic peptide from the internal region of human TM4SF4
애플리케이션
Anti-TM4SF4 antibody has been used in immunoblotting.
생화학적/생리학적 작용
TM4SF4 (Transmembrane 4 L6 Family member 4) can intervene density-dependent cell proliferation. TM4SF4 levels increases in non-dividing epithelial cells during their differentiation and migration of intestinal crypts. TM4SF4 levels are upregulated in 80% of hepatocellular carcinoma (HCC) tissues and in stomach adenocarcinoma cells. Reduction of TM4SF4 expression in HCC cell lines by stably transfecting TM4SF4 antisense plasmid caused significant inhibition of cell proliferation.
물리적 형태
The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatocellular carcinoma and accelerates tumor cell growth
Li Y, et al.
Acta biochimica et biophysica Sinica, 44(3), 224-232 (2012)
Soo-Im Choi et al.
Oncotarget, 5(20), 9823-9837 (2014-10-27)
Transmembrane 4 L six family member 4 (TM4SF4) is a member of the tetraspanin L6 domain family. Other members of this family, TM4SF1 (also known as L6-Ag) and TM4SF5, have been shown to be upregulated in multiple tumors and involved
B M Wice et al.
The Journal of biological chemistry, 270(37), 21907-21918 (1995-09-15)
The human cell line HT-29 provides a model system for studying regulation of proliferation and differentiation in intestinal epithelial cell lineages: (i) HT-29 cells cultured in glucose resemble undifferentiated multipotent transit cells located in the lower half of intestinal crypts;
Ying Li et al.
Acta biochimica et biophysica Sinica, 44(3), 224-232 (2012-01-13)
The human transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein (TM4SF4/il-TMP) was originally cloned as an intestinal and liver tetraspan membrane protein and mediates density-dependent cell proliferation. The rat homolog of TM4SF4 was found to be
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