추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
2E12E6, monoclonal
형태
buffered aqueous solution
분자량
antigen 5 kDa
종 반응성
human
농도
~1 mg/mL
기술
immunoblotting: 0.25-0.5 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92).
indirect ELISA: 30-60 ng/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92) for coating.
동형
IgG1
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ADM (133)
일반 설명
Monoclonal Anti-MR-Pro ADM (mid-regional pro adrenomedullin) (mouse IgG1 isotype) is derived from the hybridoma 2E12E6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human recombinant protein. Mid-regional pro-adrenomedullin (MR-proADM) is obtained as a by-product of post-translational processing of prepro adrenomedullin (Adm, AM) peptide. This gene is located on human chromosome 11p15.
면역원
human MR-Pro ADM recombinant protein.
애플리케이션
Anti-MR-pro ADM has been used in immunoblotting (~5 kDa) and indirect enzyme-linked immunosorbent assay (ELISA).
생화학적/생리학적 작용
Mid-regional pro-adrenomedullin (MR-proADM) has been suggested as a biomarker for plasma concentrations of adrenomedullin as it is stoichiometrically generated and relatively stable in the plasma. Upregulated levels of MR-pro ADM were associated with an increased risk of mortality and morbidity in patients with heart failure, independent of natriuretic peptides. It can stimulate vascular endothelial barrier function.
물리적 형태
a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis
Matson BC, et al.
Fertility and Sterility, 109(6), 1072-1078 (2018)
Mid-Regional Pro-Adrenomedullin (MR-proADM) as a Biomarker for Sepsis and Septic Shock: Narrative Review
Healthcare (Basel, Switzerland) , 6(3), 110-110 (2018)
Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population
Glorioso N, et al.
PLoS ONE, 8(10), e77562-e77562 (2013)
Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease)
Xie Z, et al.
Journal of Leukocyte Biology, 103(4), 749-759 (2018)
Mihael Potocki et al.
Current heart failure reports, 9(3), 244-251 (2012-06-27)
Circulating biomarkers have become increasingly important in diagnosing and risk-stratifying patients with heart failure (HF). While the natriuretic peptides have received much focus in the past decade, there is increasing interest in the role of other circulating biomarkers such as
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