SAB4200685

Anti-Glucagon antibody, Mouse monoclonal

clone K79bB10, purified from hybridoma cell culture

• 동의어(들): Monoclonal Anti-Glucagon antibody produced in mouse, GCG, GLP1, GLP2, GRPP
• UNSPSC 코드: 51111800
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: K79bB10, monoclonal
• 형태: buffered aqueous solution
• 종 반응성: cat, rabbit, mouse, guinea pig, rat, dog, porcine, zebrafish, human
• 포장: antibody small pack of 25 μL
• 농도: ~1 mg/mL
• 기술: immunohistochemistry: 5-10 μg/mL using heat−retrieved formalin-fixed, paraffin-embedded Rat pancreas sections and Biotin/ExtrAvidin^®-Peroxidase staining system.; radioimmunoassay: suitable
• 동형: IgG1
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: cat ... Gcg(101097825) ; dog ... Gcg(403571) ; guinea pig ... Gcg(100135526) ; human ... GCG(2641) ; mouse ... Gcg(14526) ; pig ... Gcg(397595) ; rabbit ... Gcg(100341777) ; rat ... Gcg(24952)

설명

일반 설명

Glucagon is a hormone peptide produced in Langerhans islets α-cells in the pancreas. The active form of glucagon is derived from the cleavage of preproglucagon (GCG). Additional cleavage peptides are oxyntomodulin and glucagon-like peptide-1 (GLP1).

면역원

Polymerized porcine glucagon

애플리케이션

Monoclonal Anti-Glucagon antibody produced in mouse has been used in immunofluorescence staining. The product may be used in several immunochemical techniques including immunohistochemistry and radioimmunoassay (RIA).

생화학적/생리학적 작용

The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis and ketogenesis. Glucagon has an antagonistic effect in the maintenance of normoglycemia to those of insulin and is suppressed by GLP1. Thus up-regulation of glucagon is leading to increased blood glucose levels. Glucagon-specific antibodies would prove useful as a Langerhans islets α cell, glucagonomas and tumor markers applying immunohistochemical techniques, and as an analytical tool in quantification of the hormone.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

법적 정보

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable