SAB4200631

Monoclonal Anti-CYBA antibody produced in mouse

clone CB-64, purified from hybridoma cell culture

• 동의어(들): Cytochrome b558 subunit alpha, Neutrophil cytochrome b 22 kDa polypeptide, Superoxide-generating NADPH oxidase light chain subunit, cytochrome b-245 alpha polypeptide, p22-PHOX
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: CB-64, monoclonal
• 형태: buffered aqueous solution
• 종 반응성: bovine, mouse, rat, monkey, human, canine
• 농도: ~1 mg/mL
• 기술: flow cytometry: 5-10 μg/test using HeLa cells.; immunoblotting: 0.5-1 μg/mL using whole extracts of HeLa cells.; immunofluorescence: 5-10 μg/mL using HeLa cells.
• 동형: IgM
• UniProt 수납 번호: P13498
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CYBA(1535) ; mouse ... Cyba(13057) ; rat ... Cyba(79129)

설명

일반 설명

Monoclonal Anti-CYBA (mouse IgM isotype) is derived from the hybridoma CB-64 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the internal region of human CYBA, conjugated to keyhole limpet hemocyanin (KLH). The small subunit, p22phox subunit, also known as cytochrome b245, alpha polypeptide/light chain (CYBA) is membrane bound,which is expressed in phagocytic, endothelial and vascular smooth muscle cells. This gene is located on human chromosome16q24

면역원

Synthetic peptide corresponding to a sequence at the internal region of human CYBA .

애플리케이션

Monoclonal Anti-CYBA antibody produced in mouse has been used in:

• immunoblotting
• flow cytometry
• immunofluorescence

생화학적/생리학적 작용

In prostate cancer cells downregulation of cytochrome b245, alpha polypeptide/light chain (CYBA) was reported to inhibited cell proliferation and colony formation, through AKT and ERK1/2 signaling pathways, indicating CYBA has a role in tumor angiogenesis and tumor growth. Mutations in this gene causes an autosomal recessive forms of chronic granulomatous disease (AR220CGD).

물리적 형태

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable