추천 제품
생물학적 소스
rabbit
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
형태
buffered aqueous solution
분자량
~60 kDa
종 반응성
rat, human
기술
immunoblotting: 1:1,000-1:2,000 using rat kidney extracts (S1 fraction)
immunohistochemistry: 1:50-1:100 using formalin-fixed paraffin-embedded human duodenum
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... SLC40A1(30061)
rat ... Slc40a1(170840)
일반 설명
SLC40A1 (also known as ferroportin, FPN1), also called iron-regulated transporter 1 (IREG1), is an iron transporter expressed in liver, duodenum and kidney. SLC40A1 is also expressed in the brain, duodenal mucosa, in neuronal cells and endothelial cells of the blood-brain barrier.
면역원
synthetic peptide corresponding to an internal sequence of human SLC40A1, conjugated to KLH.
애플리케이션
Anti-SLC40A1 antibody produced in rabbit has been used in western blotting and immunohistochemistry.
생화학적/생리학적 작용
Ferroportin 1(FPN1) plays a central role in systemic iron homeostasis and is critical for normal intestinal iron absorption. SLC40A1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Hepcidin binds to and inhibits solute carrier family FPN1, thus preventing enterocytes of the intestines from secreting iron into the hepatic portal system, thereby functionally reducing iron absorption. Ferroportin in neuronal cells is required for cellular Fe2+ export, a process critical for normal neuronal function. It has been shown to interact with amyloid precursor protein (APP), to facilitate the iron export process from neuronal cells. Mutations in the FPN1 gene have been linked to hereditary hemochromatosis, a common disorder characterized by iron overload and multi-organ damage.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Differential regulation of estrogen in iron metabolism in astrocytes and neurons
Xu M, et al.
Journal of Cellular Physiology, 234(4), 4232-4242 (2019)
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan A, et al.
Cell Metabolism, 1(3), 191-200 (2005)
Jinzhe Mao et al.
Development (Cambridge, England), 137(18), 3079-3088 (2010-08-13)
Neural tube defects (NTDs) are some of the most common birth defects observed in humans. The incidence of NTDs can be reduced by peri-conceptional folic acid supplementation alone and reduced even further by supplementation with folic acid plus a multivitamin.
A T McKie et al.
Molecular cell, 5(2), 299-309 (2000-07-06)
Iron absorption by the duodenal mucosa is initiated by uptake of ferrous Fe(II) iron across the brush border membrane and culminates in transfer of the metal across the basolateral membrane to the portal vein circulation by an unknown mechanism. We
Natascha A Wolff et al.
Journal of cellular and molecular medicine, 15(2), 209-219 (2009-12-18)
Ferroportin 1 (FPN1) is an iron export protein expressed in liver and duodenum, as well as in reticuloendothelial macrophages. Previously, we have shown that divalent metal transporter 1 (DMT1) is expressed in late endosomes and lysosomes of the kidney proximal
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