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SAB4200370

Sigma-Aldrich

Anti-PVRL4 antibody, Mouse monoclonal

clone N4.101.10, purified from hybridoma cell culture

동의어(들):

Monoclonal Anti-Nectin-4/PVRL4 antibody produced in mouse, Monoclonal Anti-PVRL4 antibody produced in mouse, Anti-EDSS1, Anti-LNIR, Anti-Nectin-4, Anti-PRR4, Anti-PVRL4, Anti-Poliovirus receptor-related 4

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모든 사진(2)

About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified from hybridoma cell culture

항체 생산 유형

primary antibodies

클론

N4.101.10, monoclonal

형태

buffered aqueous solution

종 반응성

human

농도

~1.0 mg/mL

기술

flow cytometry: 5-10 μg/test using using 1x106 MDA-MB-231 cells
immunocytochemistry: 2.5-5 μg/mL using using MDA-MB-231 cells

동형

IgG1

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... PVRL4(81607)

일반 설명

Monoclonal Anti-Nectin-4/PVRL4 (mouse IgG1 isotype) is derived from the hybridoma R2.525.2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human nectin4-Fc recombinant protein. Nectin-4 belongs to the family of Nectins. It forms homo-cis-dimers and then homo- or hetero-trans-dimers through the extracellular region in a Ca2+-independent manner. Nectin-4 is expressed in placenta, ductal breast carcinoma and lung adenocarcinomas. It is one of the plasma membrane components of adherens junctions.

면역원

human Nectin4/Fc recombinant protein

애플리케이션

Monoclonal Anti-PVRL4 antibody produced in mouse has been used in immunocytochemistry and flow cytometry.

생화학적/생리학적 작용

Nectin-4 is involved in cell adhesion through trans homophilic and heterophilic interactions. Mutations in this gene are associated with ectodermal dysplasia-syndactyly syndrome type 1.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Nectin-4 is a new histological and serological tumor associated marker for breast cancer
Fabre-Lafay S, et al.
BMC Cancer, 7(1), 73-73 (2007)
Stephanie Fabre et al.
The Journal of biological chemistry, 277(30), 27006-27013 (2002-05-16)
Nectins form a family of integral molecules that belong to the immunoglobulin superfamily. Their ectodomain is made of three Ig-like domains (V, C, C). This family comprises at least five members, namely nectin1, -2, -3, -4, and poliovirus receptor (PVR)
Francesco Brancati et al.
American journal of human genetics, 87(2), 265-273 (2010-08-10)
Ectodermal dysplasias form a large disease family with more than 200 members. The combination of hair and tooth abnormalities, alopecia, and cutaneous syndactyly is characteristic of ectodermal dysplasia-syndactyly syndrome (EDSS). We used a homozygosity mapping approach to map the EDSS

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