SAB4200366

Anti-IKZF1/IKAROS antibody, Mouse monoclonal

clone E1.14, purified from hybridoma cell culture

• 동의어(들): Anti-Hs.54452, Anti-IK1, Anti-IKAROS family zinc finger 1, Anti-LYF1, Anti-PRO0758, Anti-ZNFN1A1, Anti-hIk-1
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• 결합: unconjugated
• 항체 형태: purified from hybridoma cell culture
• 항체 생산 유형: primary antibodies
• 클론: E1.14, monoclonal
• 양식: buffered aqueous solution
• 분자량: antigen ~55 kDa
• 종 반응성: rat, monkey, human, mouse
• 농도: ~1.0 mg/mL
• 기술: flow cytometry: suitable; immunocytochemistry: 0.25-0.5 μg/mL using Jurkat cells; indirect immunofluorescence: suitable; western blot: 0.25-0.5 μg/mL using Ramos cells
• 동형: IgG2b
• UniProt 수납 번호: Q13422
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... IKZF1(10320)

설명

일반 설명

Monoclonal Anti- IKZF1 (Ikaros family zinc finger protein 1)/IKAROS (mouse IgG2b isotype) is derived from the hybridoma E1.14 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide located at the C-terminus human IKZF1/IKAROS. The IKAROS gene encodes a family of hemopoietic specific zinc finger transcriptional regulator proteins, which binds to specific DNA target sequences consisting of TGGGAA consensus motif.

면역원

a peptide located at the C-terminus human IKZF1/IKAROS.

애플리케이션

Monoclonal Anti-IKZF1 (Ikaros family zinc finger protein 1)/IKAROS antibody produced in mouse has been used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry
• flow cytometry

생화학적/생리학적 작용

Ikaros family zinc finger protein 1 (IKZF1)/IKAROS activity is essential for the generation of B cell precursors. Ikaros is essential at the earliest stage of T cell and B cell specification. In adults, however, lymphoid lineages rely on Ikaros at distinct phases of their development. Mutations or polymorphisms are associated with human B-cell acute lymphoblastic leukemia (B-ALL). Ikaros functions as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL) and B-ALL. Ikaros deletion was detected in patients with blast-phase myeloproliferative neoplasms.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable