추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~43 kDa
종 반응성
mouse, human
농도
~1.0 mg/mL
기술
indirect immunofluorescence: 1-2 μg/mL using HeLa cells
western blot: 1-2 μg/mL using HepG2 and A431 cell lysates
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pSer409)
유전자 정보
human ... TARDBP(23435)
mouse ... Tardbp(230908)
일반 설명
Transactive response DNA-binding protein 43 (TDP-43) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs). It has two RNA-recognition motifs and a glycine-rich C-terminal sequence. TDP-43 is expressed in heart, lung, liver and brain, which is localized to the nucleus..
면역원
synthetic peptide containing phosphorylated Ser409 of human TDP-43 conjugated to KLH. The corresponding sequence is identical in mouse TDP-43
애플리케이션
Anti-phospho-TDP-43 [pSer409] antibody produced in rabbit has been used in:
- enzyme linked immuno sorbent assay (ELISA)
- immunohistochemistry
- immunoblotting
- immunofluorescence
생화학적/생리학적 작용
Transactive response DNA-binding protein 43 (TDP-43) binds to single stranded RNA. It regulates transcription regulation in human immunodeficiency virus (HIV). TDP-43 is the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS). Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites. Mutations in TDP-43 is associated with ALS. Abnormal phosphorylation of TDP-43 at Ser409/410 is observed in FTLD-U and ALS, leading to apoptosis.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Emily Feneberg et al.
Molecular neurobiology, 55(10), 7789-7801 (2018-02-21)
TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
Sreedharan J, et al.
Science (New York, N.Y.), 319(5870), 1668-1672 (2008)
Yuting Ren et al.
Frontiers in neurology, 12, 663637-663637 (2021-07-02)
Objective: The aim of this study was to measure both plasma and cerebrospinal fluid (CSF) TAR DNA-binding protein 43 (TDP-43) and phosphorylated TDP-43 (pTDP-43) levels in sporadic amyotrophic lateral sclerosis (sALS) patients, and to compare them with that of healthy
Towards a TDP-43-based biomarker for ALS and FTLD
Feneberg E, et al.
Molecular Neurobiology, 55(10), 7789-7801 (2018)
TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?
Broeck LV, et al.
Trends in Molecular Medicine, 20(2), 66-71 (2014)
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