생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
분자량
antigen ~160 kDa
종 반응성
human
포장
antibody small pack of 25 μL
향상된 검증
recombinant expression
Learn more about Antibody Enhanced Validation
농도
~1.5 mg/mL
기술
western blot: 0.8-1.6 μg/mL using extracts of HEK-293T cells overexpressing human AS160
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TBC1D4(9882)
일반 설명
AS160 is a protein kinase B (Akt) substrate of 160 kDa, also known as TBC1D4. This gene is mapped to human chromosome 13q22.2 and encodes a Rab guanosine triphosphatase (GTPase)-activating protein (RabGAP). It has a number of insulin-regulatable protein kinase B (AKT) phosphomotifs. AS160 is expressed in many differentiated tissues such as adipocytes and skeletal muscles.
애플리케이션
Anti-AS160 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
생화학적/생리학적 작용
AS160 (protein kinase B (Akt) substrate) is known to play an inhibitory role in the transport of glucose transporter 4 (GLUT4) vesicles. AS160 is associated with GLUT4 vesicles in basal states and dissociates in response to insulin. Reduced expression of AS160 in adipocytes has been shown to increase plasma membrane levels of GLUT4 in an insulin-dependent manner.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Insulin-induced effects on the subcellular localization of AKT1, AKT2 and AS160 in rat skeletal muscle
Zheng X and Cartee GD
Scientific Reports, 6(4), 39230-39230 (2016)
A method to identify serine kinase substrates Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
Kane S, et al.
The Journal of biological chemistry, 277(25), 22115-22118 (2002)
Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells
Baus D, et al.
Cellular Signalling, 20(12), 2237-2246 (2008)
Cooperative actions of Tbc1d1 and AS160/Tbc1d4 in GLUT4-trafficking activities
Hatakeyama H, et al.
The Journal of Biological Chemistry, 294(4), 1161-1172 (2019)
Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease
Schwenk RW, et al.
Cardiovascular Research, 79(2), 249-258 (2008)
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