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Merck
모든 사진(1)

Key Documents

SAB4200017

Sigma-Aldrich

Anti-MUC1 antibody , Mouse monoclonal

clone 1D1, purified from hybridoma cell culture

동의어(들):

Anti-CD227, Anti-EMA, Anti-H23AG, Anti-KL-6, Anti-MAM6, Anti-Mucin1, Anti-PEM, Anti-PEMT, Anti-PUM

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified from hybridoma cell culture

항체 생산 유형

primary antibodies

클론

1D1, monoclonal

형태

buffered aqueous solution

분자량

antigen 160-500 kDa

종 반응성

human

농도

~1.0 mg/mL

기술

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
radioimmunoassay: suitable
western blot: 0.5-1.0 μg/mL using T47D cell lysates

동형

IgG1

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... MUC1(4582)

일반 설명

Monoclonal Anti-MUC1 (mouse IgG1 isotype) is derived from the hybridoma 1D1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with semi-purified MUC1 from pleural effusion of a breast cancer patient. The Mucin 1 (MUC1) gene encodes a membrane bound glycosylated phosphoprotein, belonging to the family of mucins which are heavily glycosylated proteins. Muc1 is a type I transmembrane glycoprotein with a unique extracellular domain containing 20 amino acid variable number tandem repeat (VNTR) domain. In many epithelia, this protein is attached to the apical surface by a transmembrane domain. The degree of glycosylation varies with cell type. The MUC1 gene is mapped to human chromosome 1q22.

면역원

semi purified MUC1 from pleural effusion of a breast cancer patient.

애플리케이션

Monoclonal Anti-MUC1 antibody produced in mouse has been used in:
  • immunoblotting
  • enzyme linked immunosorbent assay (ELISA)
  • radioimmunoassay
  • immunoprecipitation
  • immunocytochemistry

생화학적/생리학적 작용

Mucin 1 (Muc1) exhibits protective action by binding to pathogens and is also associated with cell signaling capacity. Upregulation of this gene, abnormal intracellular localization and varied glycosylation of Muc1 has been associated with carcinomas. Muc1 might serve as a candidate for single chain antibody mediated targeted therapy in MUC1 expressing cancers. They are preferentially expressed by a variety of adenocarcinomas, including breast, prostate, ovarian and pancreatic carcinomas as well as malignant plasma cells of multiple myelomas.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

법적 정보

Purchase of this product conveys a non-exclusive license to use the product for research purposes only. Purchase of this product does not convey a right to (i) incorporate or use the product in the manufacture of any commercial product, (ii) sell or otherwise transfer the product to any third party, or (iii) use the product to provide any commercial service. THE PRODUCT IS NOT FOR IN VIVO HUMANS USE.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

The MUC1 oncoprotein as a functional target: immunotoxin binding to alphabeta junction mediates cell killing
Rubinstein DB, et al.
International Journal of Cancer. Journal International Du Cancer, 124(1), 46-54 (2009)
Rubinstein, D.B., et al.
International Journal of Cancer. Journal International Du Cancer, 124, 6-54 (2009)
MUC1: a target molecule for cancer therapy
Singh R and Bandyopadhyay D
Cancer Biology & Therapy, 6(4), 481-486 (2007)
Mucins in cancer: protection and control of the cell surface
Hollingsworth MA and Swanson BJ
Nature Reviews. Cancer, 4(1), 45-45 (2004)
Genetic variation in C20orf54, PLCE1 and MUC1 and risk of upper gastrointestinal cancers in Caucasian populations.
Palmer A J, et al.
European Journal of Cancer Prevention, 21(6), 541-541 (2012)

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