SAB3500816

Anti-CMPK2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• UNSPSC 코드: 12352203
• NACRES: NA.41
• 결합: unconjugated
• application: ELISA; IF; WB
• 클론: polyclonal
• 종 반응성: mouse, rat, human
• citations: 2
• 기술: ELISA: suitable; immunofluorescence: suitable; western blot: suitable

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: predicted mol wt 49 kDa
• 종 반응성: mouse, rat, human
• 기술: ELISA: suitable; immunofluorescence: suitable; western blot: suitable
• UniProt 수납 번호: Q5EBM0
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CMPK2(129607)

설명

일반 설명

Cytidine/uridine monophosphate kinase 2 (CMPK2) is expressed in mitochondria. The protein Cmpk2 is similar to thymidylate kinase than to cytosolic Cmpk1. Cmpk2 has thymidylate kinase domain and the C-terminal domain contains all the consensus motifs: P-loop (ATP/ GTP binding motif A), LID (domain in lipase) domain, adenine-base binding loop, catalytic site, and potential substrate binding site. In human chromosome, the gene is localized on 2p25.2.

생화학적/생리학적 작용

Cmpk2 utilizes ATP (adenosine triphosphate) as phosphate donor to phosphorylate dUMP (deoxyuridine monophosphate), dCMP (deoxycytidine monophosphate), CMP (cytosine monophosphate), and UMP (uridine monophosphate). The order of substrate specificity for Cmpk2 is UMP, the highest, followed by dCMP, CMP and UMP. Cmpk2 also phosphorylates monophosphate nucleoside analogs ddC (zalcitabine), dFdC (gemcitabine), araC (vidarabine), BVDU (brivudine), and FdUrd (fluorodeoxyuridine). Cmpk2 expression is found in leukemic cells like chronic myelogenous leukemia K-562 and lymphoblastic leukemia MOLT-4, implicates its pathophysiology. The catalytic activity of Cmpk2 is similar to human adenylate kinase 9.

특징 및 장점

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결합

The action of this antibody can be blocked using blocking peptide SBP3500816.

물리적 형태

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable