SAB3500046

Anti-RSPO1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-CRISTIN3, Anti-R-spondin1, Anti-RSPO
• UNSPSC 코드: 12352203
• NACRES: NA.41
• 클론: polyclonal
• application: ELISA (i); IF; IHC; WB
• 종 반응성: rat, human, mouse
• 기술: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• citations: 5

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 종 반응성: rat, human, mouse
• 기술: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI 수납 번호: NP_001033722
• UniProt 수납 번호: Q2MKA7
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... RSPO1(284654)

설명

일반 설명

R-spondin 1 (RSPO1) is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular β-catenin, thereby regulating functions mediated by β-catenin such as cell fate decisions and embryonic patterning. It possesses two furin-like cysteine-rich domains at the amino-terminus, a thrombospondin domain and a carboxy-terminal tail. At least two isoforms of RSPO1 are known to exist. RSPO1 antibody will not cross-react with RSPO family members. The gene encoding RSPO1 is localized on human chromosome 1p34.3.

면역원

RSPO1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human RSPO1.

애플리케이션

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry-frozen tissue (1 paper)

생화학적/생리학적 작용

RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

결합

The action of this antibody can be blocked using blocking peptide SBP3500046.

물리적 형태

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable