추천 제품
생물학적 소스
goat
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
human, rat, mouse, canine
기술
indirect ELISA: suitable
western blot: suitable
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... PODXL(5420)
관련 카테고리
일반 설명
PODXL (podocalyxin like) is an anti-adhesive transmembrane protein which belongs to the sialomucin protein family. It is associated with cancer development and aggressiveness. The protein is expressed in various cells including epithelial cells of kidney glomeruli, vascular endothelial cells, hematopoietic stem cells and platelets. The gene encoding PODXL is localized on human chromosome 7q32.3.
면역원
Peptide with sequence C-DNLTKDDLDEEEDTH from the C Terminus of the protein sequence according to NP_001018121.1 ; NP_005388.2.
생화학적/생리학적 작용
PODXL (podocalyxin like) acts as an anti-adhesion molecule in kidney open filtration pathways. It interacts with the actin-binding protein ezrin in cancer. Using ezrin and the bridging protein NHERF (Na+/H+) exchanger regulatory factor, it connects to the cytoskeleton to regulate cytoskeletal-related functions in tumor progression. In human, PODXL stimulates the cell adherence capacity to immobilized ligands and vascular endothelial cells in presence of integrins.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin.
Susana L
Cancer Research (2007)
Genome wide analysis of novel copy number variations duplications/deletions of different epileptic patients in Saudi Arabia
Muhammad M
BMC Genomics (2015)
Li Ling et al.
International journal of molecular medicine, 41(5), 2704-2714 (2018-02-14)
Diabetic nephropathy (DN) is one of the most common complications associated with type I and II diabetes mellitus. Long noncoding RNAs (lncRNAs) have been implicated in various physiological and pathological processes, and recent evidence has demonstrated that they are involved in the process
Cheng-Wei Lin et al.
International journal of oncology, 45(2), 710-718 (2014-05-14)
Metastasis-mediated death remains a major challenge in cancer treatment due to the lack of identifiable biomarkers for early diagnosis. Identifying tumor-specific biomarkers is critical for the development of diagnostic and therapeutic tools. In the present study, we found that podocalyxin-like
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