추천 제품
생물학적 소스
goat
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
human
기술
indirect ELISA: suitable
western blot: suitable
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... GPR40(2864)
일반 설명
G protein-coupled receptor 40 (GPR40) belongs to the G protein-coupled receptors. It is a 300 amino acid protein, that has seven characteristic transmembrane domains. GPR40 is also known as FFA1 (free fatty acid receptor 1). It is expressed in the β cell of the pancreas, spinal cord and brain. It is located on human chromosome 19q13.
면역원
Peptide with sequence CAARTQGGKSQK from the C Terminus of the protein sequence according to NP_005294.1.
생화학적/생리학적 작용
G protein-coupled receptor 40 (GPR40) maintains insulin and glucose homeostasis. It plays an important role in the development of type 2 diabetes. GPR40/FFA1 signaling may participate in the regulation of endogenous pain control systems. It is considered as an anti-diabetic drug target.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
Briscoe Celia P, et al.
The Journal of Biological Chemistry, 278(13), 11303-11311 (2003)
A single amino acid mutation (R104P) in the E/DRY motif of GPR40 impairs receptor function
Guo Shimeng, et al.
PLoS ONE, 10(10), e0141303-e0141303 (2015)
A New Pain Regulatory System via the Brain Long Chain Fatty Acid Receptor GPR40/FFA1 Signal.
Nakamoto, et al.
Yakugaku Zasshi, 137(2), 199-204 (2017)
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