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Merck
모든 사진(4)

주요 문서

SAB1401100

Sigma-Aldrich

Anti-CYC1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

동의어(들):

UQCR4

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

종 반응성

mouse, human

기술

western blot: 1 μg/mL

NCBI 수납 번호

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

유전자 정보

human ... CYC1(1537)

일반 설명

Cytochrome c1 (CYC1) is a heme-containing constituent of mitochondrial complex III. It is encoded by the gene mapped to human chromosome 8q24.3. The encoded protein is attached to the phospholipid bilayer by a single C-proximal transmembrane segment.

면역원

CYC1 (NP_001907.2, 1 a.a. ~ 325 a.a) full-length human protein.

Sequence
MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK

생화학적/생리학적 작용

Cytochrome c1 (CYC1) stimulates oxidative phosphorylation activity in human ductal carcinoma in- situ (DCIS) and thus, plays an essential role in cell proliferation and comedo necrosis. CYC1 expression is implicated in breast cancer progression and might act as a predictive factor for poor prognosis in breast cancer patients. Variation in the gene expression leads to mitochondrial complex III deficiency.

물리적 형태

Solution in phosphate buffered saline, pH 7.4

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.
Chishiki M, et al.
Cancer Science, 108(7), 1510-1519 (2017)
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer
Han Y, et al.
Disease Markers (2016)
Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3.
Duncan AM, et al.
Genomics, 400-401 (1994)
Pauline Gaignard et al.
American journal of human genetics, 93(2), 384-389 (2013-08-06)
Many individuals with abnormalities of mitochondrial respiratory chain complex III remain genetically undefined. Here, we report mutations (c.288G>T [p.Trp96Cys] and c.643C>T [p.Leu215Phe]) in CYC1, encoding the cytochrome c1 subunit of complex III, in two unrelated children presenting with recurrent episodes

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