추천 제품
형태
buffered aqueous glycerol solution
Quality Level
특이 활성도
≥100 units/mg protein (Lowry)
분자량
34.2 kDa
외래 활성
Phospholipase C ≤1%
저장 온도
2-8°C
유전자 정보
Bacillus cereus ATCC 10987 ... spH(2751530)
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일반 설명
Sphingomyelinase (SMase) is a hydrolase, of 34.2 kDa and its active site contain as a minimum of two magnesium atoms.
애플리케이션
Sphingomyelinase from Bacillus cereus has been used:
- in the study to analyse the effect of sphingomyelinase on Rubella virus infectivity in cell lines
- in lipoprotein modification for the generation of cholesterol crystals in vitro
- to aggregate LDL (low-density lipoprotein)
Sphingomyelinase has been used in a study to assess the interaction of actin with the HIV-1 accessory protein Nef. Sphingomyelinase has also been used in a study to investigate X-ray scattering as a quality-control tool for liposomal drug-delivery systems.
생화학적/생리학적 작용
Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.
Sphingomyelin phosphodiesterase (SMPD) participates in the metabolic reactions comprising sphingomyelin. SMPD has the ability to prevent colorectal carcinoma and colitis.
단위 정의
One unit will hydrolyze 1.0 μmole of TNPAL-sphingomyelin per min at pH 7.4 at 37 °C.
물리적 형태
Solution in 50% glycerol containing 50 mM Tris-HCl, pH 7.5.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis)
Han L, et al.
Journal of Insect Science, 18(5), 20-20 (2018)
Raymond Tan et al.
Experimental and molecular pathology, 94(1), 51-57 (2012-06-23)
The HIV-1 accessory protein Nef is considered to play an important role in the development of a podocyte phenotype in HIV-1 associated nephropathy. We hypothesized that Nef may be altering the podocyte phenotype both structurally and functionally. To elucidate the
Analysis of the Effect of Sphingomyelinase on Rubella Virus Infectivity in Two Cell Lines
Otsuki N, et al.
Journal of virology (2017)
Extracellular lipids accumulate in human carotid arteries as distinct three-dimensional structures and have proinflammatory properties
Lehti S, et al.
The American Journal of Pathology, 188(2), 525-538 (2018)
The Bacillus cereus group
Molecular Medical Microbiology, 1041-1078 (2015)
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