추천 제품
product name
Swainsonine, synthetic
생물학적 소스
synthetic
Quality Level
분석
≥99% (HPLC)
형태
solid
solubility
methanol: 5 mg/mL, clear, colorless to light yellow
저장 온도
−20°C
SMILES string
O[C@@H]1CCCN2C[C@@H](O)[C@@H](O)C12
InChI
1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7?,8-/m1/s1
InChI key
FXUAIOOAOAVCGD-DCDLSZRSSA-N
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일반 설명
Swainsonine is produced by endophytes, plant and insect pathogens. It is synthesized from the pipecolic acid and mevalonic acid. Swainsonine is a water-soluble indole alkaloid.
애플리케이션
Swainsonine has been used:
- to test its effect on neural stem cell proliferation
- to inhibit α-mannosidase in TC-1 tumor cells
- to inhibit β1,6-branching synthesis in hepatocellular carcinoma (HCC) cells
Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II. It inhibits glycoprotein processing and also acts as immune modulator.
생화학적/생리학적 작용
Swainsonine is an inhibitor of α-mannosidase in endoplasmic reticulum and Golgi apparatus. It also activates the natural killer cells. Swainsonine elicits neurologic toxicity and its exposure impairs learning and memory resulting in cognitive deficit. It inhibits hepatocellular carcinoma and sensitizes them to respond to anti-cancer drug paclitaxel.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Swainsonine biosynthesis genes in diverse symbiotic and pathogenic fungi
Cook D, et al.
G3 (Bethesda, Md.), 7(6), 1791-1797 (2017)
Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory
Wang J, et al.
Toxicology Letters, 232(1), 263-270 (2015)
Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population
SilveiraCRF, et al.
PLoS ONE, 14(3), e0213184-e0213184 (2019)
N-glycosylation by N-acetylglucosaminyltransferase V enhances the interaction of CD147/basigin with integrin beta1 and promotes HCC metastasis
Cui J, et al.
The Journal of Pathology, 245(1), 41-52 (2018)
Caio Raony Farina Silveira et al.
PloS one, 14(3), e0213184-e0213184 (2019-03-07)
Cervical cancer, caused by high oncogenic risk Human Papillomavirus (HPV) infection, continues to be a public health problem, mainly in developing countries. Using peptide phage display as a tool to identify potential molecular targets in HPV associated tumors, we identified
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