S6949

β-Synuclein V70M histidine-tagged human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

• 동의어(들): SNCB
• MDL number: MFCD08705537
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 재조합: expressed in E. coli
• Quality Level: 200
• 분석: ≥90% (SDS-PAGE)
• 양식: lyophilized powder
• UniProt 수납 번호: Q16143
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: human ... SNCB(6620)

설명

생화학적/생리학적 작용

Acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein.

Synucleins (α, β, γ-synoretin) are a family of small, highly conserved proteins expressed primarily in neurons and certain tumors. β-Synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein. It has been postulated that β-synuclein could act as a physiological inhibitor of α-synuclein aggregation and that it might protect the central nervous system from the neurotoxic effects of α-synuclein. The mechanisms of β-synuclein neuroprotection may involve direct interaction between β-synuclein and Akt, and thus suggest that this signaling pathway could be a therapeutic target for neurological conditions associated with Parkinson and α-synuclein aggregation. Overexpression of β-synuclein mutants (P123H and V70M) in neuroblastoma cells results in enhanced lysosomal pathology suggesting a causative role for these missense mutations in neurodegeneration stimulation.

물리적 형태

Lyophilized from a 0.2 μm filtered solution.

재구성

Reconstitute with 0.5 mL water (~1 mg/mL). Store in working aliquots at −20 °C.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)