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Merck
모든 사진(1)

Key Documents

S6760

Sigma-Aldrich

Span® 80

nonionic surfactant

동의어(들):

Sorbitane monooleate, sorbitan oleate

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC 코드:
12161900
PubChem Substance ID:
NACRES:
NA.25

Quality Level

분자량

428.62 g/mol

농도

≥60% (GC)

HLB

4.3

응용 분야

microbiology

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1

InChI key

NWGKJDSIEKMTRX-AAZCQSIUSA-N

일반 설명

Span® 80 is a nonionic surfactant.

애플리케이션

Span® 80 has been used in a study to assess transfersomes as a transdermal delivery system for sertraline. It has also been used in a study to investigate the dominant factors affecting the stability of nanoemulsions through the use of artificial neural networks (ANNs).

기타 정보

Fatty acid composition: Oleic acid (C18:1) ≤ 60%; balance primarily linoleic (C18:2), linolenic (C18:3) and palmitic (C16:0) acids.

법적 정보

Span is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves


시험 성적서(COA)

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문서 라이브러리 방문

Ankit Gupta et al.
Scientia pharmaceutica, 80(4), 1061-1080 (2012-12-25)
The aim of the present study was to investigate transfersomes as a transdermal delivery system for the poorly soluble drug, sertraline, in order to overcome the troubles associated with its oral delivery. Different transfersomal formulations were prepared with non-ionic surfactant
Jean-François Cotte et al.
International journal of pharmaceutics, 436(1-2), 233-239 (2012-06-21)
Mass spectrometry (MS) and high performance liquid chromatography coupled to mass spectrometry (HPLC-MS) techniques were developed to characterize two surfactants, cetheareth-12 and sorbitan oleate, used to manufacture AF03, an emulsified oil-in-water (O/W) adjuvant. MS was first used to characterize the
Hoang Hirschberg et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(1-2), 1-7 (2012-02-15)
In the search for an optimal approach for the transcutaneous immunization (TCI) of hepatitis B surface antigen (HBsAg), two vesicle formulations, L595 vesicles (composed of sucrose-laurate ester and octaoxyethylene-laurate ester) and sPC vesicles (composed of soybean-phosphatidylcholine and Span-80) were prepared
Chenguang Zhou et al.
Molecular pharmaceutics, 9(2), 201-210 (2011-12-14)
Nonionic surfactant vesicles, or SPANosomes (SPs), comprised of cationic lipid and sorbitan monooleate (Span 80) were synthesized and evaluated as small interfering RNA (siRNA) vectors. The SPs had a mean diameter of less than 100 nm and exhibited excellent colloidal
Xiazhong Ren et al.
International journal of pharmaceutics, 431(1-2), 130-137 (2012-05-03)
This study is the first to investigate and demonstrate the potential of microemulsions (MEs) for sustained release parenteral drug delivery, due to phase transition behavior in aqueous environments. Phase diagrams were constructed with Miglyol 812N oil and a blend of

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