S5566

Anti-α-Synuclein antibody, Mouse monoclonal

clone Syn211, purified from hybridoma cell culture

• 동의어(들): Anti-SNCA
• MDL number: MFCD02095740
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: Syn211, monoclonal
• 형태: buffered aqueous solution
• 분자량: antigen 19 kDa
• 종 반응성: zebra finch, human
• 반응하면 안 됨: rat, mouse
• 포장: antibody small pack of 25 μL
• 농도: ~1 mg/mL
• 기술: immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: 0.25 μg/mL using recombinant human α·-synuclein.
• 동형: IgG1
• UniProt 수납 번호: P37840
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SNCA(6622)

설명

일반 설명

The SNCA (synuclein α) gene codes for a 140-amino acid protein α-synuclein, that is mapped to human chromosome 4q21-23.

The SNCA (synuclein α) gene is mapped to human chromosome 4q22.1. The gene encodes a small synaptic protein called α-synuclein.

면역원

recombinant human α synuclein.

애플리케이션

Anti-α-Synuclein antibody, Mouse monoclonal has been used in western blotting and ELISA.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)
Immunocytochemistry (1 paper)

생화학적/생리학적 작용

Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Synuclein-α is known to induce oligodendrocyte maturation. The encoded protein is considered to be an important aggregate of Lewy bodies, contributing to the pathogenesis of Parkinson disease.

Synuclein-α is known to induce oligodendrocyte maturation. Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Mutations in the SNCA gene results in Parkinson′s disease.

물리적 형태

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 1 % bovine serum albumin and 15 mM sodium azide.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable