S4447

α-Synuclein E46K human

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

• 동의어(들): NACP (Non-a-beta component of Alzheimer disease amyloid, precursor), PARK1, PARK4, PD1, non A4 component of amyloid precursor
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 재조합: expressed in E. coli
• Quality Level: 200
• 분석: ≥90% (SDS-PAGE)
• 양식: lyophilized powder
• 분자량: apparent mol wt 19-20 kDa
• UniProt 수납 번호: P37840
• 호환성: for use with ABI StepOnePlus
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: human ... SNCA(6622)

설명

생화학적/생리학적 작용

Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A tran­sition resulting in a Glu⁴⁶-to-Lys (E46K) substitution in the amino-terminal region of the protein.

Deposition of α-synuclein as fibrillary tangles is a hallmark of certain neurodegenerative diseases including Parkinson′s. Among the familial mutations of α-synuclein, E46K has the greatest potential to aggregate.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)