S3396

Monoclonal Anti-Spectrin (α and β) antibody produced in mouse

clone SB-SP1, ascites fluid

• MDL number: MFCD00164739
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• 결합: unconjugated
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: SB-SP1, monoclonal
• 포함: 15 mM sodium azide
• 종 반응성: human
• 기술: indirect immunofluorescence: suitable using erythrocyte smears; microarray: suitable; western blot: 1:500 using extract of human erythrocyte ghosts or purified human erythrocyte spectrin
• 동형: IgG1
• UniProt 수납 번호: P02549; P11277
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SPTA1(6708) , SPTB(6710)

설명

일반 설명

Monoclonal anti-Spectrin (α and β) (mouse IgG1 isotype) is produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass.

Spectrins are heterotetramers, that are composed of several αand β subunit isoforms. They are the constituents of G-protein-coupled receptor (GPCR) and the synaptic multiprotein complex. α-Spectrin has 20 spectrin repeats (α1-α20) and β-spectrin has 17 spectrin repeats (β1-β17). SPTA1 (spectrin α 1) is located on chromosome 1q21–q23 and SPTB (spectrin β) is located on chromosome 14q22–q23.2.

특이성

This antibody reacts specifically with the α and β chains of human erythrocyte spectrin.

면역원

human erythrocyte spectrin.

애플리케이션

Anti-Spectrin (α and β) antibody has been used in western blotting and immunostaining.

Monoclonal Anti-Spectrin (α and β) antibody produced in mouse has been used in flow cytometry analysis and confocal microscopy.

생화학적/생리학적 작용

Spectrins are multifunctional proteins, that modulates the cell morphology and mechanical properties. Spectrins also participates in the cell cycle by controlling the upregulation of membrane receptors. α- and β-spectrins are essential for the development of nervous system.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable