S178
(R)-SKF-82957 hydrobromide
solid
동의어(들):
(1R)-6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1H-3-benzazepine-7,8-diol hydrobromide, 1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-3-methyl-1-phenyl hydrobromide hydrobromide
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C17H18ClNO2 · HBr
CAS Number:
Molecular Weight:
384.70
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
형태
solid
Quality Level
광학 활성
[α]22/D +22.46°, c = 0.76 in DMF(lit.)
색상
white
solubility
H2O: 7.5 mg/mL
DMSO: soluble
SMILES string
Br[H].CN1CCc2c(Cl)c(O)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO2.BrH/c1-19-8-7-12-13(9-15(20)17(21)16(12)18)14(10-19)11-5-3-2-4-6-11;/h2-6,9,14,20-21H,7-8,10H2,1H3;1H/t14-;/m1./s1
InChI key
BCZHWHQKKPEORG-PFEQFJNWSA-N
생화학적/생리학적 작용
Selective D1 dopamine receptor agonist.
주의사항
hygroscopic, photosensitive
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
F R Pfeiffer et al.
Journal of medicinal chemistry, 25(4), 352-358 (1982-04-01)
6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines were synthesized and evaluated as agonists of central and peripheral dopamine receptors. These benzazepines were prepared by cyclization of certain amino alcohols followed by demethylation of the 7,8-dimethoxy groups of the precursors to the 7,8-catecholic moiety. Preliminary evidence of
P H Andersen et al.
European journal of pharmacology, 188(6), 335-347 (1990-06-12)
Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds
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