추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
human
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8 μg/mL using human pancreas, Islets of Langerhans
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
유전자 정보
human ... SSTR1(6751)
mouse ... Sstr1(20605)
rat ... Sstr1(25033)
일반 설명
Somatostatin Receptor Type 1 (SSTR1) is present in blood vessels, neuroendocrine cells, and the retina. SSTR1 gene is mapped to human chromosome 14q21.1.
면역원
synthetic peptide corresponding to the C-terminal of human somatostatin receptor type 1, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
생화학적/생리학적 작용
Somatostatin Receptor Type 1 (SSTR1) protein extracellular loop regions are crucial for ligand binding. SSTR1 gene down-regulated in reported in preeclampsia but it is overexpressed in breast cancer. It is reported to block the mitogen-activated protein kinase (MAPK) pathway. However, in pancreatic cell lines, elevated expression of SSTR1 gene favors cell cycle arrest. SSTR1 also plays a tumor suppressor role in gastric cancer invasion.
물리적 형태
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
J Zhao et al.
British journal of cancer, 108(12), 2557-2564 (2013-06-01)
Somatostatin receptor 1 (SSTR1) was preferentially methylated in Epstein-Barr virus (EBV)-positive gastric cancer using promoter methylation array. We aimed to analyse the epigenetic alteration and biological function of SSTR1 in EBV-associated gastric cancer (EBVaGC). Promoter methylation was examined by combined
Yi Zou et al.
Oncology letters, 17(2), 1723-1731 (2019-01-25)
Somatostatin receptors (SSTRs) are G-protein-coupled plasma membrane receptors that have been determined to be expressed in normal and cancer tissues. Activation of SSTRs frequently results in inhibition of cell proliferation and therefore somatostatin analogues (SSAs) have been used in cancer
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