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Merck
모든 사진(1)

주요 문서

S1076

Sigma-Aldrich

SRC, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

동의어(들):

ASV, c-SRC, p60-Src

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About This Item

UNSPSC 코드:
12352200
NACRES:
NA.32

재조합

expressed in E. coli

Quality Level

제품 라인

PRECISIO® Kinase

분석

≥70% (SDS-PAGE)

양식

buffered aqueous glycerol solution

특이 활성도

83-113 nmol/min·mg

분자량

~83 kDa

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... SRC(6714)

일반 설명

SRC proto-oncogene, non-receptor tyrosine kinase (SRC) belongs to the family of non-receptor tyrosine kinases. SRC was originally identified as a transforming protein of the Rous sarcoma virus (RSV) that had enzymatic ability to phosphorylate tyrosine in protein substrates. It contains an amino-terminal domain, conserved Src-homology domains (SH2 and SH3), a tyrosine kinase domain and the carboxyl-terminus. The gene encoding this protein is localized on human chromosome 20q11.23.

애플리케이션

SRC, active, GST tagged human has been used in the in vitro kinase assay.

생화학적/생리학적 작용

SRC proto-oncogene, non-receptor tyrosine kinase (SRC) phosphorylates membrane proteins and nucleoproteins and activates various intracellular signaling cascades. It is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. In addition to increasing cell proliferation, a key role of SRC in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumor progression.

물리적 형태

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

법적 정보

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Min Yu et al.
Microbiology and immunology, 65(1), 40-47 (2020-10-08)
The ischemia-reperfusion-induced damage in human brain microvascular endothelial cells (BMECs) is associated with disruption of the blood-brain barrier. CXC chemokine ligand 5 (CXCL5) is reported to be up-regulated in ischemic stroke. However, the detailed function of CXCL5 in this pathological
ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.
Lievens PM
Molecular and Cellular Biology, 36(17), 2208-2225 (2016)
C Jacobs et al.
Cancer research, 43(4), 1696-1702 (1983-04-01)
An endogenous protein of human cells pp60c-src, which is closely related to the product of the transforming gene of Rous sarcoma virus, pp60v-src, has been quantitated by measuring its enzymatic activity in an immunoglobulin G protein kinase assay. The influence
The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin aIIb?3 to Initiate Outside-in Signaling in Platelets.
Wu Y
The Journal of Biological Chemistry, 290(25), 290(25)-290(25) (2015)
SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane.
Machiyama H
FEBS Journal, 282(20), 4034-4055 (2015)

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