S0198

Monoclonal Anti-Sonic Hedgehog peptide (N-terminal) antibody produced in rat

clone 171001, purified immunoglobulin, lyophilized powder

• 동의어(들): Anti-Dsh, Anti-Hhg1, Anti-Hx, Anti-Shh
• UNSPSC 코드: 51111800
• NACRES: NA.41

속성

• 생물학적 소스: rat
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 171001, monoclonal
• 양식: lyophilized powder
• 종 반응성: mouse, human
• 기술: western blot: 1-2 μg/mL
• 동형: IgG2a
• UniProt 수납 번호: Q15465
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SHH(6469) ; mouse ... Shh(20423)

설명

면역원

purified, E. coli-derived recombinant mouse 6× histidine-tagged sonic hedgehog N-terminal peptide (aa 25-198).

생화학적/생리학적 작용

Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, gamma catenin, myc and other transcription factors. The Hh family members have multiple roles such as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during the development of brain and nervous system.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)