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Merck
모든 사진(1)

주요 문서

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R121

Sigma-Aldrich

S(−)-Raclopride (+)-tartrate salt

>97%, solid

동의어(들):

3,5-Dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxybenzamide (+)-tartrate salt

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C15H20Cl2N2O3 · C4H6O6
CAS Number:
98185-20-7
Molecular Weight:
497.32
MDL number:
MFCD00274072
UNSPSC 코드:
12352200
PubChem Substance ID:
24277931
NACRES:
NA.77

Quality Level

100

분석

>97%

양식

solid

색상

white

solubility

H2O: 89 mg/mL

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC

InChI

1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1

InChI key

QULBVRZTKPQGCR-NDAAPVSOSA-N

유전자 정보

human ... DRD2(1813)

애플리케이션

S(−)-Raclopride (+)-tartrate salt has been used as a D2 receptor antagonist:
  • to study the role of the D2 receptor in mediating ventrolateral PAG (vlPAG)/dorsal raphe dopaminergic antinociceptive effect in animals
  • in pharmacological and behavioral studies performed with Thap1 null mice
  • to determine the relationship between Ca2+ transients and dopamine neuron activity in rats

생화학적/생리학적 작용

Raclopride is a benzamide derivative and a selective D2 dopamine receptor antagonist.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

주의사항

Photosensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
BCCC6896
BCBW8974
BCBS7358
BCBQ6483V
BCBQ6483

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문서 라이브러리 방문

J Kopp et al.
Neuroscience, 47(4), 771-779 (1992-01-01)
Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this study we used the dopamine D2 receptor antagonist raclopride
Angel Toval et al.
Molecular neurobiology, 58(4), 1782-1791 (2021-01-05)
Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a healthy
P Protais et al.
European journal of pharmacology, 271(1), 167-177 (1994-12-12)
S 14506 (1-[-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piper azine hydrochloride), 8-OH-DPAT ((+/-)-8-hydroxydipropylaminotetralin hydrobromide), clozapine and raclopride were compared in some behavioural models able to characterize dopamine antagonist properties. In mice treated with apomorphine (0.75 mg/kg, s.c.), stereotyped climbing and sniffing were dose dependently antagonized by
H Lublin et al.
Psychopharmacology, 112(2-3), 389-397 (1993-01-01)
The effects of chronic treatment with dopamine (DA) D1 and D2 receptor antagonists were evaluated in eight cebus apella monkeys with mild oral dyskinesia after previous haloperidol treatment. SCH 23390 (D1 antagonist) was given daily to investigate the direct behavioural
Andrew G Yee et al.
Journal of neurochemistry, 148(4), 462-479 (2018-09-12)
Despite the importance of somatodendritic dopamine (DA) release in the Substantia Nigra pars compacta (SNc), its mechanism remains poorly understood. Using a novel approach combining fast-scan controlled-adsorption voltammetry (FSCAV) and single-unit electrophysiology, we have investigated the mechanism of somatodendritic release

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