추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
room temp
SMILES string
Fc1ccc(cc1)C(=O)N2CC(C2)(COc3cc4c(cc(cc4)OC)cc3)C(=O)O
InChI
1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)
InChI key
LWJGMYMNSNVCEM-UHFFFAOYSA-N
애플리케이션
PF-04418948 has been used in TG (trigeminal ganglion) explant culture.
생화학적/생리학적 작용
PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
PF-04418948 represses the formation of colorectal tumor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats.
Zhang P, et al.
Journal of Neuroinflammation, 15(1), 117-117 (2018)
Prostaglandin E 2-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment.
Aoki T and Narumiya S
Inflammation and regeneration, 37(1), 4-4 (2017)
Eva Mangelsen et al.
Cells, 9(5) (2020-05-23)
Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman's space. Elevated Prostaglandin E2 (PGE2) synthesis and upregulated cyclooxygenase 2 (Cox2) are associated with podocyte
문서
Sigma-Aldrich offers many products related to prostanoid receptors for your research needs.
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