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P9521

Sigma-Aldrich

21-Deoxycortisol

동의어(들):

11β,17α-Dihydroxy-4-pregnene-3,20-dione, 11β,17α-Dihydroxyprogesterone, 21-Desoxycortisol, 4-Pregnene-11β,17α-diol-3,20-dione

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C21H30O4
CAS Number:
641-77-0
Molecular Weight:
346.46
EC Number:
211-375-7
MDL number:
MFCD00056476
UNSPSC 코드:
41116107
PubChem Substance ID:
24899039
NACRES:
NA.77

생물학적 소스

synthetic (organic)

Quality Level

200

분석

≥98.00% (TLC)

형태

powder

solubility

ethanol: 9.80-10.20 mg/mL, clear, colorless

배송 상태

ambient

저장 온도

room temp

SMILES string

CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C

InChI

1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1

InChI key

LCZBQMKVFQNSJR-UJPCIWJBSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

21-Deoxycortisol is a 17-hydroxyprogesterone derivative. It serves as a marker for congenital adrenal hyperplasia, an autosomal recessive disorder, indicated by 21-hydroxylase deficiency.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

Radha Chaube et al.
Theriogenology, 105, 90-96 (2017-09-25)
In the present study, distribution of steroid hormones (estradiol-17β (E
Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency
Costa BFA, et al.
Clin. Endocrinol., 73(6), 700-706 (2010)
J L Sadoul et al.
European journal of endocrinology, 141(3), 238-245 (1999-09-04)
An increased response of 17-hydroxyprogesterone to ACTH stimulation has been observed in adrenal incidentaloma and linked to an impairment of either 21-hydroxylase or of 11beta-hydroxylase activity. To analyse this question further, we investigated the steroidogenic pathways in a series of
H Blanché et al.
Human genetics, 101(1), 56-60 (1998-01-07)
21-hydroxylase (21-OH) deficiency accounts for the vast majority of nonclassic (NC) forms of congenital adrenal hyperplasia (CAH), and is associated with symptoms detectable either in childhood (precocious puberty) or sometimes only later in adulthood (hirsutism, acne, amenorrhea). While the severe
Simone Cristoni et al.
Rapid communications in mass spectrometry : RCM, 18(1), 77-82 (2003-12-23)
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder mainly caused by 21-hydroxylase deficit (21-OHD). Deletions or mutations of the CYP21 gene induce the impairment of glucocorticoid and mineralcorticoid synthesis. 17-Hydroxyprogesterone (17-OHP) is the hormonal marker in patients, but not
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