P4904

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine hydrate

≥98%

• 동의어(들): 1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, 1-O-Palmityl-2-acetyl-sn-glycero-3-phosphocholine monohydrate, 2-Acetyl-1-hexadecyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, 1-hexadecyl-2-acetyl, PAF(C₁₆), Platelet activating factor
• 실험식(Hill 표기법): C₂₆H₅₄NO₇P · xH₂O
• CAS Number: 74389-68-7
• Molecular Weight: 523.68 (anhydrous basis)
• Beilstein: 3574588
• MDL number: MFCD00150679
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24898570
• NACRES: NA.77

속성

• 분석: ≥98%
• 형태: powder
• 저장 온도: −20°C
• SMILES string: O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
• InChI: 1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
• InChI key: HFMSDOHEENWULV-UFTMZEDQSA-N

설명

애플리케이션

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine has been used:

• to study its effects on phagocytic activity and production of superoxide anion in equine alveolar macrophage and blood neutrophils
• to study its protective effects against cisplatin-induced cell death in a human melanoma cell line in vitro
• to determine its effects on cervical ripening and leukocyte infiltration in rat models

생화학적/생리학적 작용

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine or platelet-activating factor (PAF), is a phospholipid, and a pro-inflammatory lipid mediator. It acts as a ligand for G protein-coupled platelet-activating factor (PAF) receptors and participates in several biological processes such as airway constriction, hypotension, platelet activation, and increased vascular permeability. PAF is released by various cells such as platelets, neutrophils, endothelial cells, and monocytes/macrophages. The levels of PAF are low in the blood due to its rapid metabolism by PAF acetylhydrolase and low production.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)