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Merck
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주요 문서

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P4359

Sigma-Aldrich

Pifithrin-α

≥95% (HPLC), powder

동의어(들):

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide, PFT-α

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About This Item

Linear Formula:
C16H18N2OS·HBr
CAS Number:
63208-82-2
Molecular Weight:
367.30
MDL number:
MFCD00417851
UNSPSC 코드:
12352200
PubChem Substance ID:
24898529
NACRES:
NA.77

분석

≥95% (HPLC)

양식

powder

저장 조건

protect from light

색상

off-white

mp

192.1-192.5 °C (lit.)

solubility

DMSO: 20 mg/mL

배송 상태

wet ice

저장 온도

−20°C

SMILES string

Br[H].Cc1ccc(cc1)C(=O)CN2C(=N)SC3=C2CCCC3

InChI

1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H

InChI key

HAGVCKULCLQGRF-UHFFFAOYSA-N

애플리케이션

Pifithrin-α has been used:
  • to study the effect of specific p53 inhibitor on p53-upregulated modulator of apoptosis (PUMA) expression after transient global cerebral ischemia (tGCI)
  • as p53 inhibitor to treat PA1 cells
  • as a tumor protein p53 (TRP53) inhibitor, to treat mouse lung epithelial-12 (MLE-12) cells

생화학적/생리학적 작용

Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin, etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Pifithrin-α protects mice from lethal whole body γ-irradiation without an increase in cancer incidence. The protective effect is not seen in p53-null mice or cells expressing a dominant negative mutant of the p53 gene. Protection is conferred by the transient expression of p53 in p53-deficient cell lines.

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
063M4741V
BGBB9988
121M4601V
060M4637
019K46003

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Growth arrest is one of the essential features of cellular senescence. At present, the precise mechanisms responsible for the establishment of the senescence-associated arrested phenotype are still incompletely understood. Given that ERK1/2 is one of the major kinases controlling cell
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Stroke, 40(2), 618-625 (2009)
E A Komarova et al.
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The p53 protein is traditionally believed to be a tumor suppressor. Activation of p53-dependent apoptosis in response to damage to cell DNA provides for the elimination of possible tumor cell precursors. However, in some cases the activity of p53 can
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관련 콘텐츠

Discover Bioactive Small Molecules for Apoptosis

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