추천 제품
양식
solid
solubility
H2O: ≤24 mg/mL
SMILES string
Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3
InChI
1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H
InChI key
QUJWFJNHTBKCLU-UHFFFAOYSA-N
유전자 정보
human ... OPRS1(10280)
rat ... Oprs1(29336) , Slc6a3(24898)
관련 카테고리
생화학적/생리학적 작용
PRE-084 is a potent and highly selective σ1 opioid receptor agonist. It offers neuroprotection upon embolic stroke.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
T Maurice et al.
British journal of pharmacology, 127(2), 335-342 (1999-06-29)
1. Sigma (sigma) receptor ligands were previously reported to alleviate learning and memory impairments on several pharmacological and pathological rodent models of amnesia. Such effect was demonstrated as involving the sigma1 subtype of sigma receptor. 2. In this study, we
Stefanie Vogler et al.
Neuroscience letters, 610, 13-18 (2015-10-27)
Water accumulation in retinal glial (Müller) and neuronal cells resulting in cellular swelling contributes to the development of retinal edema and neurodegeneration. Sigma (σ) receptor activation is known to have neuroprotective effects in the retina. Here, we show that the
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
Allahtavakoli M and Jarrott B
Brain Research Bulletin, 85(3-4), 219-224 (2011)
Yuriko Kimura et al.
PloS one, 8(10), e75760-e75760 (2013-10-12)
Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (CNS). For that, it is considered as an
Yan-Lin He et al.
Neuroscience bulletin, 34(5), 759-768 (2018-04-20)
Cyproheptadine (CPH), a first-generation antihistamine, enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway. In this study, we aimed to determine the effects of CPH on neuronal excitability in
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.