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Merck
모든 사진(1)

주요 문서

O1012

Sigma-Aldrich

Oleoyl coenzyme A lithium salt

≥90% (HPLC)

동의어(들):

cis-9-Octadecenoyl coenzyme A

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C39H68N7O17P3S
CAS Number:
188824-37-5
Molecular Weight:
1031.98
UNSPSC 코드:
41106305
NACRES:
NA.51

Quality Level

200

분석

≥90% (HPLC)

양식

powder

solubility

H2O: soluble-50 mg/mL, clear, colorless

저장 온도

−20°C

애플리케이션

Coenzyme A functions as an acyl group carrier, acetyl-CoA. Oleoyl coenzyme A (Oleoyl-CoA) may be used to study the specificity and kinetics of enzymes such as acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) involved in long chain fatty acid cholesterol esterification.

생화학적/생리학적 작용

Oleoyl-CoA is an important substrate, that is essential for the biosynthesis of 1-Alkyl-2,3-diacylglycerol (ADG) and very long chain monounsaturated fatty acids of harderian gland (HG) 1-alkyl-2,3-diacylglycerol.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
089K5064V
089K5064
114K70211
116K7025
038K5057

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문서 라이브러리 방문

Ta-Yuan Chang et al.
American journal of physiology. Endocrinology and metabolism, 297(1), E1-E9 (2009-01-15)
The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles
Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs.
Leon C, Hill JS, Wasan KM.
Pharmaceut. Res., 22, 1578-1588 (2005)
Mariana Igoillo-Esteve et al.
International journal for parasitology, 41(3-4), 429-438 (2010-12-18)
Metabolism in trypanosomatids is compartmentalised with major pathways, notably glycolysis, present in peroxisome-like organelles called glycosomes. To date, little information is available about the transport of metabolites through the glycosomal membrane. Previously, three ATP-binding cassette (ABC) transporters, called GAT1-3 for
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2, 3-diacylglycerol
Miyazaki M, et al.
The Journal of Biological Chemistry, 276(42), 39455-39461 (2001)
Catherine C Y Chang et al.
Biochemistry, 49(46), 9957-9963 (2010-10-23)
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a membrane-bound enzyme utilizing long-chain fatty acyl-coenzyme A and cholesterol to form cholesteryl esters and coenzyme A. Previously, we had expressed tagged human ACAT1 (hACAT1) in CHO cells and purified it to homogeneity; however
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