추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~230 kDa (extracellular)
antigen ~280 kDa
종 반응성
human
농도
~1 mg/mL
기술
western blot: 1:500-1:1,000
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... NOTCH2(4853)
mouse ... Notch2(18129)
rat ... Notch2(29492)
일반 설명
NOTCH homolog-2 (NOTCH2) is part of the NOTCH signaling pathway and the gene encoding it is localized on chromosome 1p13-p11.
면역원
synthetic peptide corresponding to residues 1718-1733 of human NOTCH2. This sequence is 93% identical in mouse and rat.
생화학적/생리학적 작용
NOTCH homolog-2 (NOTCH2) is a stimulator of metaplasia in goblet cells, which is seen in respiratory diseases like asthma. Mutations in the NOTCH2 gene are associated with Hajdu-Cheney syndrome.
물리적 형태
solution in phosphate buffered saline, containing 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
A novel NOTCH2 mutation identified in a Korean family with Hajdu-Cheney syndrome showing phenotypic diversity.
Han MS
Annals of Clinical and Laboratory Science, 45(1), 110-114 (2015)
Hajdu-Cheney syndrome: a review.
Canalis E and Zanotti S
Orphanet Journal of Rare Diseases, 9, 200-200 (2014)
NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine.
Dong Y
Stem Cells Translational Medicine, 3(12), 1456-1466 (2014)
Henry Danahay et al.
Cell reports, 10(2), 239-252 (2015-01-06)
The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. A hallmark of airway diseases is epithelial remodeling, leading to increased goblet cell numbers and an overproduction of mucus. In the conducting airway, basal cells act
Johan Boström et al.
PloS one, 12(12), e0188772-e0188772 (2017-12-12)
The cell cycle coordinates core functions such as replication and cell division. However, cell-cycle-regulated transcription in the control of non-core functions, such as cell identity maintenance through specific transcription factors (TFs) and signalling pathways remains unclear. Here, we provide a
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