N3908

Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 동의어(들): NGFR Antibody - Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit, Ngfr Antibody
• MDL number: MFCD00675539
• UNSPSC 코드: 51111800
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 종 반응성: rat
• 향상된 검증: functional assay; Learn more about Antibody Enhanced Validation
• 기술: immunohistochemistry (frozen sections): 1:10,000 using rat brain; indirect immunofluorescence: 1:500 using NGF-treated PC12 cells; microarray: suitable; western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells
• UniProt 수납 번호: P07174
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: rat ... Ngfr(24596)

설명

일반 설명

Nerve growth factor receptor (NGFR) is encoded by the gene mapped to rat chromosome 10. In rats, immunoreactivity of NGFR has been observed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the brain.

Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.

면역원

synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.

애플리케이션

Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:

• immunoprecipitation
• immunocytochemistry
• immunohistochemistry
• immunoblotting

생화학적/생리학적 작용

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable