N3415

Nifurtimox

≥98% (HPLC)

• 동의어(들): (RS)-3-methyl-N-[(1E)-(5-nitro-2-furyl)methylene]thiomorpholin-4-amine 1,1-dioxide, (±)-Nifurtimox, 3-Methyl-4-(5′-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide; 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine 1,1-dioxide, BAY 2502, Thiomorpholine, 3-methyl-4-((5-nitrofurfurylidene)amino)-,1,1-dioxide
• 실험식(Hill 표기법): C₁₀H₁₃N₃O₅S
• CAS Number: 23256-30-6
• Molecular Weight: 287.29
• EC Number: 245-531-0
• MDL number: MFCD00869254
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329818609
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: yellow to orange
• solubility: DMSO: ≥13 mg/mL
• 주관자: Bayer
• 저장 온도: room temp
• SMILES string: CC1CS(=O)(=O)CCN1\N=C\c2ccc(o2)[N+]([O-])=O
• InChI: 1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+
• InChI key: ARFHIAQFJWUCFH-IZZDOVSWSA-N

설명

일반 설명

Nifurtimox acts as a hypoxia-activated cytotoxin, which specifically kills clonogenic tumor cells under hypoxic conditions. It is used to treat Chagas disease and African trypanosomiasis. Nifurtimox inhibits neuroblastoma and medulloblastoma cell growth.

애플리케이션

Nifurtimox has been used in drug treatment in culture media.

생화학적/생리학적 작용

Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes.

Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes. Nifurtimox was discovered empirically and its mechanism of action is unclear. It is believed that nifurtimox exerts its biological activity through the bioreduction of the nitro-group to a nitro-anion radical which undergoes redox-cycling with molecular oxygen.

특징 및 장점

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable