추천 제품
사용
sufficient for 100 fluorometric tests
응용 분야
pharmaceutical
검출 방법
fluorometric
관련 질환(들)
cardiovascular diseases
저장 온도
2-8°C
유전자 정보
human ... MTTP(4547)
일반 설명
Microsomal triglyceride transfer protein (MTP), a membrane-bound protein present in the liver, plays an important role in the assembly and secretion of very low density lipoprotein (VLDL). MTP is also necessary for assembly and secretion of chylomicrons by the intestine. This protein facilitates the transfer of triglyceride (TG), cholesteryl ester (CE) and phosphatidylcholine (PC) between phospholipid surfaces. Mutation in the MTP gene leads to abetalipoproteinemia.
애플리케이션
MTP Activity Assay Kit has been used to measure the activity of microsomal triglyceride transfer protein (MTP).
특징 및 장점
Compatible with high-throughput handling systems.
적합성
Suitable for measuring microsomal [triglyceride] transfer protein (MTP) activity in cell lysates or tissue homogenates, or for screening MTP activity inhibitors.
원리
The MTP Activity Assay Kit is a sensitive, homogeneous fluorometric assay useful for continuous measurement of MTP activity in cell lysate or tissue homogenate. This kit includes proprietary substrates that enable the detection of MTP-mediated transfer of neutral lipid. The transfer activity results in an increase in fluorescence intensity (λEx=465 nm/λEm=535 nm).
Storage Class Code
10 - Combustible liquids
Jessica Wagoner et al.
Hepatology (Baltimore, Md.), 51(6), 1912-1921 (2010-06-01)
Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo. In the current study, we further characterized silymarin's antiviral actions. Silymarin
Jonathan Goldwasser et al.
Journal of hepatology, 55(5), 963-971 (2011-03-01)
Hepatitis C virus (HCV) infection affects 3% of the world population and is the leading cause of chronic liver disease worldwide. Current standard of care is effective in only 50% of the patients, poorly tolerated, and associated with significant side
Short-term palmitate supply impairs intestinal insulin signaling via ceramide production.
Tran T T T, et al.
The Journal of Biological Chemistry, M115-M115 (2016)
J Estellé et al.
Animal genetics, 40(6), 813-820 (2009-06-06)
Despite the economic interest of the fatty acid profile in pigs, no gene has been convincingly associated with this trait so far. Here, the porcine microsomal triglyceride transfer protein (MTTP) gene, which plays a crucial role in the assembly of
Yuan-Lung Cheng et al.
Clinical science (London, England : 1979), 125(9), 439-448 (2013-05-11)
HCV (hepatitis C virus) infection affects an estimated 180 million people in the world's population. Adverse effects occur frequently with current standard treatment of interferon and ribavirin, while resistance of new direct anti-viral agents, NS3 protease inhibitors, is a major
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