M8445

Anti-MLH1 (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-COCA2, Anti-FCC2, Anti-HNPCC, Anti-MGC5172
• UNSPSC 코드: 12352203
• NACRES: NA.41
• 결합: unconjugated
• application: IP
• 클론: polyclonal
• 종 반응성: human, mouse, rat
• citations: 5
• 기술: immunoprecipitation (IP): 5-10 μg using Jurkat cell lysates

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen 80-85 kDa
• 종 반응성: human, mouse, rat
• 포장: antibody small pack of 25 μL
• 농도: ~1 mg/mL
• 기술: immunoprecipitation (IP): 5-10 μg using Jurkat cell lysates
• UniProt 수납 번호: P40692
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... MLH1(4292) ; mouse ... Mlh1(17350) ; rat ... Mlh1(81685)

설명

일반 설명

MLH1 is part of a large multi-subunit protein complex of tumor suppressors, DNA damage sensors, and signal transducers, named BRCA1-associated genome surveillance complex (BASC).

MutL homolog 1 (MLH1) is a nucleoprotein and a major component of mismatch repair system. The MLH1 gene is located in chromosome 3p21 and is made up of 19 exons. The protein has a molecular weight of 80kDa.

특이성

Anti-MLH1 (C-terminal) specifically recognizes human MLH1 (80-85 kDa).

면역원

synthetic peptide corresponding to amino acids 591-606 of human MLH1, conjugated to KLH via an N-terminal added cysteine residue. The corresponding peptide sequence is conserved in human, rat, and mouse.

애플리케이션

Anti-MLH1 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation

생화학적/생리학적 작용

A hereditary mutation in the MLH1 gene is implicated in nonpolyposis colorectal cancer-2.

MutL homolog 1 (MLH1) has been shown to be involved in promoting colorectal carcinogenesis.

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

저장 및 안정성

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

면책조항

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)