추천 제품
Quality Level
분석
≥98%
형태
solid
색상
white to off-white
solubility
DMSO: >20 mg/mL
H2O: insoluble
저장 온도
2-8°C
SMILES string
COc1cc(N)c(Cl)cc1C(=O)OCCN2CCCCC2
InChI
1S/C15H21ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h9-10H,2-8,17H2,1H3
InChI key
RVFIAQAAZUEPPE-UHFFFAOYSA-N
유전자 정보
rat ... Htr3a(79246) , Htr4(25324)
생화학적/생리학적 작용
Potent, selective 5-HT4 serotonin receptor agonist
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
D Yang et al.
Journal of medicinal chemistry, 40(4), 608-621 (1997-02-14)
A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor agonists in the electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum and the rat esophagus muscle. Monosubstitution
Jean-Louis Soulier et al.
Journal of medicinal chemistry, 48(20), 6220-6228 (2005-09-30)
Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception and the synthesis of bivalent molecules able to influence the dimerization
F De Ponti et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 13(6), 543-553 (2002-03-21)
5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also be involved. Differences may exist between the small bowel and colon. Our aims were: (i) to compare the
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