추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
lyophilized powder
분자량
antigen 180 kDa
종 반응성
rat, mouse, human
기술
immunohistochemistry: 1:1,000-1:2,000
immunoprecipitation (IP): 3 μL using 200 μg of rat brain
western blot: 1:1,000
UniProt 수납 번호
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... GRIN2A(2903)
mouse ... Grin2a(14811)
rat ... Grin2a(24409)
일반 설명
Rabbit polyclonal anti-Glutamate Receptor NMDAR2A (NR2A) antibody labels the 180 kDa NR2A subunit of the NMDA receptor. This labeling is blocked by the preadsorption of the antibody with the immunogen. The antibody does not cross-react with the NR2B or NR2C subunits. It reacts with rat, mouse and human tissues.
The N-Methyl-D-Aspartate (NMDA) receptor complex is comprised of 2 types of subunits, NR1 and NR2. Only one type of NR1 subunits has yet been identified while four distinct subunits have been identified for the NR2 receptor, NR2A, NR2B, NR2C, and NR2D. While the NR2 subunits are not functional alone, they combine with the NR1 subunit to produce a variety of different receptor types. A number have studies have also shown that the functional properties of the receptors complexes formed by the NR1 and NR2 subunits are largely determined by the NR2 components of the complex. NMDA receptors are post-synaptic and play important roles in plasticity in the developing and mature central nervous system (CNS). Agonists and antagonists of NMDA receptors have been proposed to be of therapeutic benefit in a number of CNS disorders, including stroke, head injury, epilepsy, pain, and Alzheimer′s disease.
면역원
C-terminal portion of NR2A (amino acids 1253-1391).
애플리케이션
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Rabbit polyclonal anti-Glutamate Receptor NMDAR2A (NR2A) antibody is used to tag the 180 kDa NR2A subunit of the NMDA receptor for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as immunoblotting and immunoprecipitation. It is used as a probe to determine the presence and roles of the 180 kDa NR2A subunit in the assembly and function of N-Methyl-D-Aspartate (NMDA) receptor complexes.
물리적 형태
Lyophilized from ammonium bicarbonate (5 mM)
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Jennifer Stanic et al.
Nature communications, 6, 10181-10181 (2015-12-19)
NMDA receptor (NMDAR) composition and synaptic retention represent pivotal features in the physiology and pathology of excitatory synapses. Here, we identify Rabphilin 3A (Rph3A) as a new GluN2A subunit-binding partner. Rph3A is known as a synaptic vesicle-associated protein involved in
M Cik et al.
The Biochemical journal, 296 ( Pt 3), 877-883 (1993-12-15)
The N-methyl-D-aspartate R1 (NMDAR1) and NMDAR2A subunits were expressed transiently either alone or in combination in human embryonic kidney (HEK) 293 cells. The biochemical and pharmacological properties of the cloned receptors were compared with those of adult rat brain NMDA
Sighild Lemarchant et al.
International journal of molecular sciences, 23(16) (2022-08-27)
NX210c is a disease-modifying dodecapeptide derived from the subcommissural organ-spondin that is under preclinical and clinical development for the treatment of neurological disorders. Here, using whole-cell patch-clamp recordings, we demonstrate that NX210c increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)- and GluN2A-containing N-methyl-D-aspartate
X Altafaj et al.
Neurobiology of disease, 32(3), 377-384 (2008-09-09)
Transgenic mice overexpressing Dyrk1A (TgDyrk1A), a Down syndrome (DS) candidate gene, exhibit motor and cognitive alterations similar to those observed in DS individuals. To gain new insights into the molecular consequences of Dyrk1A overexpression underlying TgDyrk1A and possibly DS motor
L Addis et al.
Scientific reports, 7(1), 66-66 (2017-03-01)
Mutations in the N-methyl-D-aspartate receptor (NMDAR) gene GRIN2A cause epilepsy-aphasia syndrome (EAS), a spectrum of epileptic, cognitive and language disorders. Using bioinformatic and patient data we shortlisted 10 diverse missense mutations for characterisation. We used high-throughput calcium-flux assays and patch
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