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Merck
모든 사진(1)

문서

M149

Sigma-Aldrich

Methiothepin mesylate salt

≥98% (HPLC), solid

동의어(들):

1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt, Metitepine mesylate salt

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모든 사진(1)

About This Item

Linear Formula:
C20H24N2S2 · CH3SO3H
CAS Number:
74611-28-2
Molecular Weight:
452.65
MDL number:
MFCD00153831
UNSPSC 코드:
12352200
PubChem Substance ID:
24278104
NACRES:
NA.77

분석

≥98% (HPLC)

형태

solid

저장 조건

desiccated

색상

white

solubility

H2O: 13 mg/mL

SMILES string

CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1

InChI

1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)

InChI key

CZMDZGZYKOGLJY-UHFFFAOYSA-N

유전자 정보

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR6(3362) , HTR7(3363)

일반 설명

Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.

애플리케이션

Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.

생화학적/생리학적 작용

Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

P Schoeffter et al.
British journal of pharmacology, 117(6), 993-994 (1996-03-01)
Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50
C Grånäs et al.
European journal of pharmacology, 380(2-3), 171-181 (1999-10-08)
Site-directed mutagenesis of the human 5-HT1B receptor was performed to investigate the role of the amino acid residues cysteine 326 and tryptophan 327 in transmembrane region VI and aspartic acid 352 in transmembrane region VII in ligand binding. Binding studies
Primary neuronal precursors in adult crayfish brain: replenishment from a non-neuronal source
Benton J L, et al.
BMC Neuroscience, 12(1), 53-53 (2011)
T Nilsson et al.
European journal of pharmacology, 372(1), 49-56 (1999-06-22)
5-Hydroxytryptamine (5-HT) can produce both vasoconstrictor and vasorelaxant effects in human coronary arteries and the response to 5-HT can be influenced by the presence of disease. The aim of the present study was to elucidate the 5-HT receptor subtypes responsible
A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas
Jia Y, et al.
Developmental and Comparative Immunology, 82, 83-93 (2018)
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