M024080

ssH-Linker

configured for PerkinElmer, configured for Polygen

• 동의어(들): 9,11-Dioxa-2-aza-10-phosphatridecanoic acid, 10-[bis(1-methylethyl)amino]-13-cyano-, 2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl este
• 실험식(Hill 표기법): C₃₈H₅₃N₄O₅P
• Molecular Weight: 676.83
• MDL number: MFCD12912425
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329817759
• NACRES: NA.51

속성

• 유형: for DNA synthesis
• 제품 라인: Proligo Reagents
• 분석: ≥98% (³¹P-NMR); ≥98.0% (reversed phase HPLC)
• 호환성: configured for PerkinElmer; configured for Polygen
• 저장 온도: −20°C
• SMILES string: COc1ccc(cc1)C(NCCOC(=O)NCCCCCCOP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c3ccccc3
• InChI: 1S/C38H53N4O5P/c1-31(2)42(32(3)4)48(47-29-16-25-39)46-28-15-7-6-14-26-40-37(43)45-30-27-41-38(33-17-10-8-11-18-33,34-19-12-9-13-20-34)35-21-23-36(44-5)24-22-35/h8-13,17-24,31-32,41H,6-7,14-16,26-30H2,1-5H3,(H,40,43)
• InChI key: VTFLXOVDKJUHER-UHFFFAOYSA-N

설명

일반 설명

ssH-linker comprises an internal carbamate group attached to the MMT-protected amino group via a short spacer. The carbamate moiety facilitates the cleavage of the MMT group under mildly acidic conditions while increasing the stability of the MMT group during the deprotection of the oligonucleotide with ammonia. The carbamate group also enhances the reactivity of the amino group through a neighbor group effect, and thereby accelerates conjugations to amino reactive modifiers and reporters. The MMT-group of ssH-linker serves as an excellent purification handle after the oligonucleotide synthesis in trityl-on mode, similar to the DMT-group of conventional oligonucleotides. The MMT-group is cleaved under very mild conditions in aqueous acetic acid (10% glacial acetic acid in the water, 20 min. room temp.) Alternatively, the MMT-group can be cleaved on the synthesis instrument with an acidic deblock solution to enable on-support labeling protocols.

법적 정보

This product is covered under US Patent Number 7,491,857

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable