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Merck
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주요 문서

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K4894

Sigma-Aldrich

Poloxamer 188

solid

동의어(들):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68

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About This Item

CAS Number:
9003-11-6
MDL number:
MFCD00082049
UNSPSC 코드:
12161902
NACRES:
NA.75

Agency

USP/NF
meets USP testing specifications

Quality Level

300

양식

solid

분자량

8.400 g/mol

pH

5.0-7.5(2.5% solution)

응용 분야

sample preservation

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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일반 설명

Poloxamer 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends.

애플리케이션

Poloxamer 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads.
Poloxamer 188 has been used as a supplement in F17 medium for the culture of HEK293-6E cells. It has also been used as a component of flow cytometry (FACS) buffer as a non-ionic detergent that protects cells from hydrodynamic damage.

생화학적/생리학적 작용

Poloxamer 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe2+ and H2O2.

법적 정보

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

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시험 성적서(COA)

Lot/Batch Number
SLCM1791
SLCL6020
SLCL1787
SLCK6898
SLCK3582

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