K0890

Anti-Potassium Channel K_v11.3 (erg3) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 동의어(들): Anti-KCNH7, Anti-ether-a-go-go-related channel 3
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: lyophilized powder
• 종 반응성: mouse, human, rat
• 기술: immunohistochemistry: suitable using rat brain sections; western blot: 1:300 using rat brain lysates
• UniProt 수납 번호: Q9NS40
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... KCNH7(90134) ; mouse ... Kcnh7(170738) ; rat ... Kcnh7(170739)

설명

일반 설명

The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7), also referred to as erg3, encodes a subunit of ether-à-go-go related (erg) K⁺ channels. The erg K⁺ channels are part of the EAG (ether-à-go-go) family of voltage-gated K⁺ channels. The encoded protein is found to be expressed in the apical membrane of the retinal pigment epithelium.

특이성

The K_V11.3 antibody is directed against an intracellular epitope of C-terminal part of K_V11.3.

면역원

synthetic peptide CPEFLDLEKSKLKSKE corresponding to amino acids 1108-1123 of rat K_V11.3.

생화학적/생리학적 작용

The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7) encodes a voltage gated K⁺ channel that modulates the membrane potential in its rested and activated state. In the nervous system, it may participate in the regulation of neuronal excitability. The erg3 channels have relatively negative activation threshold compared to erg1 and erg2. They are capable of recycling K⁺ ions to the subretinal space in the dark and contribute to the maintenance of the resting membrane potential.

물리적 형태

Lyophilized powder containing phosphate buffered saline, pH 7.4, 1% BSA and 0.025% sodium azide.

재구성

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

안전성 정보

• Storage Class Code: 10 - Combustible liquids