추천 제품
생물학적 소스
goat
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
lyophilized powder
종 반응성
human
기술
immunocytochemistry: 5-15 μg/mL
immunohistochemistry: 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL
저장 온도
−20°C
유전자 정보
human ... IL8(3576)
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일반 설명
Interleukin 8 (IL-8) is an 8kD, 72 amino acid residue containing cytokine that belongs to C-X-C chemokine family . The IL-8 gene is mapped to human chromosome 4q13.3.
특이성
The antibody will neutralize the biological activity of recombinant and natural human IL-8, but not recombinant human GROα.
면역원
recombinant human IL-8 (CXCL8).
애플리케이션
Anti-Interleukin-8 antibody can be used for the following :
- For neutralizing the biological activity of recombinant human IL-8 and natural human IL-8.
- Immunoblotting.
- ELISA.
Anti-Interleukin-8 antibody can be used in immunocytochemistry and immunohistochemistry.
생화학적/생리학적 작용
Interleukin 8 (IL-8) stimulates neutrophils to produce lysosomal enzymes along with myeloperoxidase, α-mannosidase and β-glucuronidase . Goat anti-Interleukin-8 antibody reacts specifically with recombinant and natural human IL-8 but not with recombinant human GROα. Elevated expression of the gene is observed in a number of cancers including chronic spontaneous urticaria and breast cancer, thus serves as a prognostic marker for the same. IL-8 regulates the metastasis and angiogenesis processes during cancer development. IL-8 is responsible for epithelial–mesenchymal transition which plays an important role in providing cancer cells the mobility to invade other neighbouring cells, thereby contributing to metastasis.
물리적 형태
Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Identification and validation of vesicant therapeutic targets using a high-throughput siRNA screening approach.
Ruff A L, et al.
Archives of Toxicology, 90(2), 375-383 (2016)
Properties of pro-inflammatory cell type-specific leukocyte chemotactic cytokines, interleukin 8 (IL-8) and monocyte chemotactic and activating factor (MCAF).
N Mukaida et al.
Microbiology and immunology, 36(8), 773-789 (1992-01-01)
Elevated plasma il-8 concentration is related to severity of systemic inflammation in chronic spontaneous urticaria.
Kasperska-Zajac A, et al.
Journal of Biological Regulators and Homeostatic Agents, 31(4), 957-961 (2017)
Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8.
Ji S, et al.
Oncotarget, 7(31), 49411-49411 (2016)
T Yoshimura et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(24), 9233-9237 (1987-12-01)
Stimulated human monocytes release several proteins thought to play a role in inflammation, including interleukin 1, tumor necrosis factor, and plasminogen activator. We have purified another proinflammatory protein that is chemotactic for human neutrophils from conditioned medium of lipopolysaccharide-stimulated monocytes.
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