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Merck
모든 사진(1)

주요 문서

I3901

Sigma-Aldrich

IL-1α rat

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

동의어(들):

Interleukin-1α, Lymphocyte activating factor, rIL-1α, IL-1α

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모든 사진(1)

About This Item

MDL number:
MFCD01635091
UNSPSC 코드:
12352202
NACRES:
NA.77

제품명

Interleukin-1α from rat, IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

생물학적 소스

rat

Quality Level

100

재조합

expressed in E. coli

분석

≥97% (SDS-PAGE)

양식

lyophilized powder

효능

1-10 pg/mL ED50

품질

endotoxin tested

분자량

~18 kDa

포장

pkg of 5 μg

기술

cell culture | mammalian: suitable

불순물

≤0.1 EU/μg

UniProt 수납 번호

P16598

저장 온도

−20°C

유전자 정보

rat ... Il1a(24493)

생화학적/생리학적 작용

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LA F), activates T cells and lymphocytes, which then proliferate and secrete Interleukin-2 (IL-2). The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

물리적 형태

Lyophilized from 0.2 μm filtered phosphate buffered saline containing 0.25 mg of bovine serum albumin.

분석 메모

The biological activity of recombinant rat IL-1α was measured by its ability to stimulate cell proliferation using a mouse helper T cell line, D10.G4.1.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
MKCR0785
MKCP7084
MKCN8870
MKCL5321
MKCG3572

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COA 검색

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문서 라이브러리 방문

Xuankang Wang et al.
Journal of neuroinflammation, 18(1), 256-256 (2021-11-07)
Neurotoxic microglia and astrocytes begin to activate and participate in pathological processes after spinal cord injury (SCI), subsequently causing severe secondary damage and affecting tissue repair. We have previously reported that photobiomodulation (PBM) can promote functional recovery by reducing neuroinflammation
T Nishida et al.
Journal of biochemistry, 105(3), 351-357 (1989-03-01)
A cDNA sequence coding for rat interleukin-1 alpha (IL-1 alpha) has been isolated from a cDNA library that was prepared with mRNA derived from LPS-stimulated rat peritoneal macrophages by using human IL-1 alpha cDNA as a probe. The rat cDNA
Aybike Saglam et al.
Glia, 69(4), 1022-1036 (2020-12-15)
Astrocytes are key players in CNS neuroinflammation and neuroregeneration that may help or hinder recovery, depending on the context of the injury. Although pro-inflammatory factors that promote astrocyte-mediated neurotoxicity have been shown to be secreted by reactive microglia, anti-inflammatory factors
Lilianne Barbar et al.
STAR protocols, 1(3), 100172-100172 (2020-12-31)
Given the critical roles of astrocytes in neuroinflammation and neurological diseases, models for studying human astrocyte biology are in increasing demand. Here, we present a protocol to isolate human astrocytes from induced pluripotent stem cell (iPSC)-based cultures, neural organoids, and
Kevin A Guttenplan et al.
Cell reports, 31(12), 107776-107776 (2020-06-25)
Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells (RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We show that preventing the formation of neuroinflammatory reactive astrocytes prevents the death

문서

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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