추천 제품
생물학적 소스
goat
결합
unconjugated
항체 형태
whole antiserum
항체 생산 유형
secondary antibodies
클론
polyclonal
포함
15 mM sodium azide
기술
indirect ELISA: 1:100,000
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
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일반 설명
Immunoglobulin M (IgM) is the major component of antibodies. It is the first antibody to be secreted during a primary antibody response, which is expressed in the human fetus. IgM is produced by B1 cells, which is found in blood.
특이성
The antibody preparation is specific for human IgM when tested against purified human IgA, IgG, Bence Jones Kappa and Bence Jones Lambda light chains
생화학적/생리학적 작용
IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
Immunoglobulin M (IgM) pentamer activates the classical pathway of complement activation and lysis of red blood cells. Monoclonal IgM antibodies provides protection against systemic infection and autoimmune diseases. It does not cross human placenta. IgM regulates B cell development.
물리적 형태
Supplied as a liquid containing 15 mM sodium azide as a preservative.
저장 및 안정성
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
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Measurement of cardiac troponin I (cTnI) should be feasible for point-of-care testing (POCT) to diagnose acute myocardial infarction (AMI). Lateral flow immunoassays (LFIAs) have been long implemented in POCT and clinical settings. However, sensitivity, matrix effect and quantitation in lateral
The immunological development of the human fetus
Van FR, et al.
The Journal of Experimental Medicine, 122(6), 1173-1188 (1965)
Role of natural and immune IgM antibodies in immune responses
Boes M, et al.
Molecular Immunology, 37(18), 1141-1149 (2000)
The importance of natural IgM: scavenger, protector and regulator
Ehrenstein MR and Notley, Clare A
Nature Reviews: Immunology, 10(11), 778-778 (2010)
E J Wiersma et al.
Journal of immunology (Baltimore, Md. : 1950), 160(12), 5979-5989 (1998-06-24)
Previous studies have discerned two forms of polymeric mouse IgM: moderately cytolytic (complement-activating) pentamer, which contains J chain, and highly cytolytic hexamer, which lacks J chain. To investigate the relationships among polymeric structure, J chain content, and cytolytic activity, we
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