I1286

Icariin

≥94% (HPLC)

• 동의어(들): 4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside
• 실험식(Hill 표기법): C₃₃H₄₀O₁₅
• CAS Number: 489-32-7
• Molecular Weight: 676.66
• MDL number: MFCD00210516
• UNSPSC 코드: 12352205
• PubChem Substance ID: 329815347
• NACRES: NA.25

속성

• Quality Level: 100
• 분석: ≥94% (HPLC)
• 색상: light yellow to yellow
• solubility: DMSO: 50 mg/mL, clear, colorless to dark yellow
• 응용 분야: metabolomics; vitamins, nutraceuticals, and natural products
• 저장 온도: room temp
• SMILES string: COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2
• InChI: 1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
• InChI key: TZJALUIVHRYQQB-XLRXWWTNSA-N

설명

일반 설명

Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.

애플리케이션

Icariin has been used:

• in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats
• to test its analgesic effects on lower back pain (LBP) in rats
• as a potential treatment in osteoporosis condition in rats
• to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes
• as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells

생화학적/생리학적 작용

Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.

Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable