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Merck
모든 사진(8)

주요 문서

HPA059299

Sigma-Aldrich

Anti-MAOA antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

동의어(들):

Anti-BRNRS, Anti-MAO-A

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About This Item

UNSPSC 코드:
12352203
인간 단백질 도해서 번호:
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

제품 라인

Prestige Antibodies® Powered by Atlas Antibodies

양식

buffered aqueous glycerol solution

종 반응성

human

향상된 검증

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

기술

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

면역원 서열

VLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVS

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... MAOA(4128)

일반 설명

Monoamine oxidase A (MAOA) is encoded by the gene mapped to human chromosome Xp21-p11. The encoded protein is an isoform of MAO enzyme.

면역원

monoamine oxidase A

애플리케이션

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-MAOA antibody produced in rabbit has been used in immunohistochemistry.

생화학적/생리학적 작용

Monoamine oxidase A (MAOA) catalyzes the degradation of biogenic amines such as dopamine, noradrenaline and serotonin. Increased activation of MAOA is linked to human heart failure (HF). Thus, the protein may be a potential target for the treatment of HF. Mutation in the gene leads to panic disorder (PD).

특징 및 장점

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

결합

Corresponding Antigen APREST87855

물리적 형태

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

법적 정보

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment
Brett CH, et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 135(1), 59-64 (2005)
Monoamine oxidase is overactivated in left and right ventricles from ischemic hearts: an intriguing therapeutic target
Maria EM, et al.
Oxidative Medicine and Cellular Longevity, 2016(1) (2016)
Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphism
Laurie O, et al.
Genomics, 3(1), 53-58 (1988)
Fixation and spread of somatic mutations in adult human colonic epithelium
Anna MN, et al.
Cell Stem Cell, 22(6), 909-918 (2018)
MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy
Andreas R, et al.
Molecular Psychiatry, 19(1), 122-122 (2014)

Global Trade Item Number

SKUGTIN
HPA059299-100UL4061837044632

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